化痰消瘀汤剂对胃癌前病变患者血清肿瘤标志物含量的影响

Effect of Huatan Xiaoyu decoction on serum tumor markers in patients with precancerous lesions of gastric cancer

目的:观察化痰消瘀汤剂对胃癌前病变(precancerous lesion of gastric cancer,PLGC)患者的临床疗效观察以及对肿瘤标志物的影响.方法:选取2013-07/2014-10江苏省人民医院或南京市鼓楼区虹桥社区卫生中心就诊的PLGC患者200例,其中肿瘤标志物阳性的患者占40例.患者均给予化痰消瘀汤剂,每日1剂,分早晚两次服用,疗程:6 mo,治疗前后均行电子胃镜和病理组织学检测观察临床疗效,以及运用电化学发光免疫分析法检测血清中肿瘤标志物的含量变化.结果:200例患者经化痰消瘀汤剂治疗后,总病理有效率为88%,治疗前后进行自身病理组织学对比差异有统计学意义(P<0.05).治疗前后患者血清中癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原19-9(carbohydrate antigen 19-9,CA19-9)、C A72-4、C A125的含量比较差异有统计学意义(P<0.05).结论:化痰消瘀汤剂可以逆转和阻止胃P L G C进一步发展,降低血清肿瘤标志物CEA、CA19-9、CA72-4、CA125的含量,为中药治疗PLGC降低肿瘤风险提供了客观参考依据.

AIM： To observe the clinical efficacy of HuatanXiaoyu decoction（HXD） in the treatment of precancerous lesions of gastric cancer（PLGCs）,and its effect on tumor markers in serum. METHODS： Two hundred patients with PLGCs were orally given HXD twice per day.The therapeutic course for all patients was six months. The therapeutic effi cacy was assessed,and pathological changes were evaluated after electronic gastroscopy and biopsy. Serum levels of tumor markers were determined using electrochemical luminescence immunoassay. RESULTS： Total effective rate was 88%. Symptom improvement, endoscopic and pathologic changes after treatment were significantly better than those before treatment（P 〈0.05）.The contents of carcinoembryonic antigen（CEA）, carbohydrate antigen 19-9（CA19-9）,CA72-4, and CA125 in serum were signif icantly lower after treatment than before treatment（P 〈0.05）. CONCLUSION： HXD could prevent the progression of PLGCs by lowering serum CEA,CA19-9, CA72-4 and CA125 levels. Our f indings provide an objective basis for the treatment of PLGCs to reduce the risk of cancer.