幽门螺旋杆菌感染与慢性荨麻疹发病的相关性

Role of helicobacter pylori infection in pathogenesis of chronic urticaria

目的探讨幽门螺旋杆菌(HP)感染与慢性荨麻疹(CU)发病的关系。方法应用尿素14C呼气试验对88例CU患者和43例健康体检者进行HP检测。HP(+)的CU患者随机分为治疗组和对照组,治疗组采用枸地氯雷他啶联合抗HP药物口服,对照组单独口服枸地氯雷他啶。结果 88例慢性荨麻疹CU患者中62例(70.45%)HP(+),43例健康体检者中15例(34.88%)HP(+),两者差异有统计学意义(P<0.05)。治疗组和对照组的总有效率分别为78.13%和46.67%,两组之间的总有效率差异有统计学意义(P<0.05)。结论 HP感染与慢性荨麻疹的发病有一定相关性,建议对CU患者常规进行HP检测,对于伴发HP感染的CU患者,予以抗组胺药物和抗HP药物联合治疗。

Objective To investigate the role of helicobacter pylori (HP) infection in the pathogenesis of chronic urticaria (CU). Methods 14C urea breath test was carried out to detect HP infection in 88 cases of CU patients and 43 cases of healthy controls. The CU patients with HP infection were randomly divided into treatment group and control group. Both groups were treated with oral desloratadine cit-rate combined with anti-HP therapy and single oral desloratadine citrate respectively. Results 62 (70. 45%) patients showed positive HP in 88 cases of CU, while 15 (34. 88%) healthy controls had HP infection. The difference between the two groups was statistically significant (P<0. 05). The total effective rate was 78. 13% in the treatment group, while 46. 67% in control group. The difference of total effective rate between the two groups had statistical significance (P<0. 05). Conclusion HP infection is related to the onset of chronic urticaria in some patients. HP detection is recommended in routine examination of CU patients. The combination of antihistamines and anti-HP medi-cines is suggested in treating those CU patients coexisted with HP infection.