330株大肠埃希菌的耐药性分析

Drug resistance analysis of 330 strains escherichia coli

目的：了解大肠埃希菌的分布特点及抗菌药物的耐药性，为临床合理用药提供依据。方法：用美国BD公司Phoneix-100全自动细菌鉴定药敏分析仪并部分结合手工法，对临床标本分离的大肠埃希菌进行鉴定和对14种抗菌药物敏感性检测，判断标准均根据CLSI2010年版判定。结果：330株大肠埃希菌，尿液占41.5%，居第1位；亚胺培南、头孢哌酮/舒巴坦、阿米卡星、哌拉西林/他唑巴坦普遍敏感，头孢他啶、头孢吡肟、氨曲南、头孢噻肟耐药率分别占41.5%、48.5%、49.4%、60.6%，耐药率〉70%的是哌拉西林和头孢唑啉。结论：医院大肠埃希菌多药耐药趋势明显，必须采取合理措施，防止耐药菌株的继续传播。

Objective：To understand the distribution character and the drug resistance of Escherichia coli and to provide basis for clinical therapy. Methods：Escherichia coli isolated from clinical samples were identified and 14 kinds of antimicrobial drug sensitivity were analyzed by American BD Company Phoneix-100 automatic bacteria identification and/drug sensitivity analyzer and part of the combination of manual method, judgment standard according to the CLSI2010 edition of judgment.Results：330 strains of Escherichia coli, urine accounted for 41.5%, ranking the first place; imipenem, cefoperazone/sulbactam, amikacin, piperacillin/tazobactam is sensitive, ceftazidime, cefepime, aztreonam, cefotaxime resistance rate accounted for 41.5%, 48.5%, 49.4%, 60.6%, piperacillin ampicillin and cefazolin resistant rate is more than 70%. Conclusions：Multidrug resistant strains of Escherichia coli trend obviously, must take reasonable measures to prevent the continued spread of drug-resistant strains in our hospital.