临床多重耐药肠杆菌科细菌对替加环素的体外敏感性分析研究

Sensitive analysis study in vitro of clinical multiple drug resistance enterobacteriaceae bacteria to tigecycline

目的：研究临床多重耐药肠杆菌科细菌对替加环素的体外敏感性分析，为临床治疗提供可参考依据。方法：采取稀释法检测替加环素对临床上分离出的多重耐药肠杆菌的最小抑菌浓度（MIC），同时与其他十种抗菌药物进行分析比较。结果：临床多重耐药肠杆菌科细菌对替加环素敏感率91.6%，对美罗培南敏感率90%，对头孢吡肟敏感率77.7%，对头孢他啶敏感率27.7%，对头孢曲松敏感率27.7%，对阿莫西林敏感率55.3%，对他唑巴坦敏感性0，对阿米卡星敏感性88.9%，对左氧氟沙星敏感性84.1%，对米诺环素敏感性67.9%。结论：替加环素对临床多重耐药肠杆菌科细菌体外抑菌敏感性较高，可以在临床治疗中推广应用。

Objective：To study clinical multiple drug resistant enterobacteriaceae bacteria for the in vitro sensitivity of ring element analysis, provide reference basis for clinical treatment. Methods：Take dilution test for added in multiple drug-resistant e. coli isolated from the clinical minimum bacteriostatic concentration （MIC）, at the same time with other paper analyzes ten kinds of antimicrobial agents.Results：Clinical multiple drug resistant enterobacteriaceae bacteria sensitive to add ring element for rate is 91.6%, is sensitive to beauty efaecalis rate is 90%, with cefepime sensitive rate is 77.7%, for he totally cephalosporin rate 27.7%, sensitive to ceftriaxone rate is 27.7%, sensitive rate 55.3% to amoxicillin and susceptibility to his temple sensitivity was 0%, 88.9% sensitivity to amikacin, sensitivity to levofloxacin and 84.1% 67.9% of minocycline sensitivity. Conclusions：For add ring element of clinical multiple drug-resistant enterobacteriaceae bacteria in vitro antimicrobial sensitivity is higher, can be applied in clinical treatment.