血清同型半胱氨酸与血脂水平在冠心病风险的关联分析及相关功能研究

Correlation analysis between serum homocysteine and blood lipid level in coronary heart disease risk and related function study

目的：探讨血清同型半胱氨酸与血脂水平在冠心病风险的相关性及相关功能研究。方法：选择2012年5月至2014年5月期间我院心内科收治的116例诊断为CHD的患者作为研究组，选取同时期前往我院进行健康检查的100例健康人群作为对照组，检测两组研究对象的血清Hcy及血脂水平，并分析Hcy及血脂水平对CHD的诊断价值、灵敏性及特异性以及在不同类型冠心病中的差异。结果：研究组的Hcy、TG、Lp（a）的水平均显著高于对照组，而HDL-C水平要明显低于对照组，差异均具有统计学意义（P〈0.05），而TC、LDL-C水平比较无显著性差异（P〉0.05）；其中Hcy的AUC面积最大，且Hcy及HDL-C水平比较差异无统计学意义（P〉0.05），其余指标均具有统计学意义（P〈0.05）；而HDL-C对冠心病诊断的灵敏性最高，Hcy具有较高的特异性，而TC、LDL-C及Lp（a）的诊断灵敏性均较低；不同冠心病类型组间TC、HDL-C、LDL-C的指标比较无显著性差异（P〉0.05），而Hcy、TG、Lp（a）水平均具有显著性差异，三种类型的冠心病的指标均明显高于对照组，差异均具有统计学意义（P〈0.05）。结论：血清Hcy水平升高以及HDL-C水平降低均为CHD患者的相关危险因素，能够为CHD的预防、诊断及治疗提供依据。

Objective：To investigate the correlation between serum homocysteine and blood lipid level in patients with coronary heart disease risk and to research the related functions. Methods：During the period of 2012 May to 2014 May, selected 116 cases in our hospital were admitted to Department of Cardiology diagnosis for CHD patients as research group, 100 healthy people selected from the same period to our hospital health examination as the control group, serum Hcy and serum lipid levels in two groups were detected the object of study, and analysis of blood lipids and the level of Hcy in the diagnosis of CHD value and the sensitivity and specificity and in different types of coronary heart disease differences.Results：Research group of Hcy, TG, Lp （a） levels were significantly higher than those in control group, while the HDL-C level was significantly lower than that in control group, the difference was statistically significant （P〈0.05）, but no significant difference compared with TC, the level of LDL-C （P〉0.05）; wherein Hcy AUC the largest area, no statistical significance and comparison of Hcy and HDL-C level difference （P〉0.05）, the other indexes with statistical significance （P〈0.05）; while the HDL-C on the sensitivity of the diagnosis of coronary heart disease is the highest, the specificity of Hcy is high, while TC, LDL-C and Lp （a） in the diagnosis of sensitivity are low; and there is no significant difference in different kinds of coronary heart disease between groups TC, HDL-C, the LDL-C index （P〉0.05）, while Hcy, TG, Lp （a） levels were significant differences, coronary heart disease, three types of index were significantly higher than those in control group, the difference was statistically significant （P〈0.05）. Conclusions：Elevated levels of serum Hcy and HDL-C level reduced are related risk factors of patients with CHD, the combined detection of serum Hcy and serum lipids by has the high value of CHD, which can provide the basis for prevention, diagnosis and treatment of CHD.