乳腺癌卵巢转移:18例患者的临床特征及预后

Breast cancer with ovarian metastasis: Clinical features and prognosis of 18 patients

目的 ：探讨乳腺癌卵巢转移患者的临床特征及预后。方法 ：回顾性分析2001—2013年天津医科大学肿瘤医院收治的18例乳腺癌卵巢转移患者的病历资料和随访数据。结果 ：确诊乳腺癌时的中位年龄为48岁,确诊乳腺癌卵巢转移时的中位年龄为52岁,确诊乳腺癌至确诊卵巢癌转移的中位间隔时间为50个月。卵巢转移确诊后的中位生存时间为29个月,1、3和5年生存率分别为83.3%、33.3%和11.1%。单因素分析结果显示,激素受体的表达（P=0.022）和单侧/双侧原发性乳腺癌（P=0.012）是影响卵巢转移间隔时间的因素;卵巢转移前有其他部位转移（P=0.022）和卵巢转移间隔时间较短（〈24个月）（P=0.010）的患者卵巢转移后的3年生存率较低。多因素分析结果显示,双侧原发性乳腺癌是卵巢转移间隔时间的独立预后因素[比值比：32.769（95%可信区间：3.100-346.382）]（P=0.010）;卵巢转移间隔时间[比值比：0.867（95%可信区间：0.780-0.964）]（P=0.009）是生存的独立预后因素。结论 ：双侧原发性乳腺癌患者较易发生卵巢转移;卵巢转移间隔时间较短的患者,预后也更差。

Objective： To evaluate the clinicopathological features and prognosis of 18 cases of breast cancer with ovarian metastasis. Methods： The medical records and follow-up informat cancer patients with ovarian metastasis admitted in University Cancer Institute and Hospital between 2001 retrospectively analyzed. on of 18 breast Tianjin Medical and 2013 were Results： The median age of patients at the diagnosis of breast cancer was 48 years old, and the median age of patients at the diagnosis of ovarian metastasis was 52 years old. The median interval to ovarian metastasis was 50 months. The median survival after ovarian metastasis was 29 months; 1-year, 3-year and 5-year survival rates were 83.3%, 33.3% and 11.1%, respectively. Univariate analysis showed hormone receptor status （P = 0.022） and unilateral/bilateral primary breast cancer （P = 0.012） were associated with interval to ovarian metastasis; other organ metastasis before ovarian metastasis （P = 0.022） and interval to ovarian metastasis （P = 0.010） were related to a poor 3-year survival after ovarian metastasis. Multivariate analysis showed that bilateral primary breast cancer was an independent factor related to interval to ovarian metastasis [odds ratio： 32.769 （95% confidence interval： 3.100-346.382）; P = 0.010]; the interval to ovarian metastasis was an independent factor related to a poor survival [odds ratio： 0.867 （95% confidence interval： 0.780-0.964）; P = 0.009].Conclusion： metastasis; poor progn Bilateral primary breast cancer patients are more likely to develop ovarian furthermore, the patients with a short interval to ovarian metastasis will have a osis.