GADD45在抗肿瘤治疗中的研究进展

Advances in GADD45 in anti-tumor therapy

生长抑制和DNA损伤诱导45蛋白(growth arrest and DNA damageinducible 45,GADD45)家族在DNA修复、细胞周期调控及衰老与基因毒性应激反应等多种细胞功能中起着重要的调节作用。大量研究结果显示,GADD45在肿瘤细胞中参与了多种细胞信号通路的调控,其表达的缺失与肿瘤的形成及进展密切相关。此外,许多抗肿瘤物质都是通过GADD45来发挥其抑制肿瘤生长作用的。本文总结并讨论了GADD45在多种肿瘤中的表达及调控机制,以及在多种抗肿瘤药物中的具体作用机制,以期为恶性肿瘤化疗策略的制定及新型药物的研发提供可靠的理论依据。

Growth arrest and DNA damage-inducible 45 （GADD45） protein family plays an important role in a variety of cellular functions including DNA repair, cell cycle regulation, senescence and genotoxic stress. Many studies have demonstrated that GADD45 is involved in regulation of many cell signaling pathways, and its expression deficiency is related to the initiation and progression of malignancies. Furthermore, many anti-tumor agents inhibit the growth of tumor through GADD45 signaling pathway. This review summarizes and discusses the expression of GADD45 in many kinds of tumors and the related regulatory mechanism, as well as its role in mechanism of many anti-tumor drugs, providing theoretical basis for decision of chemotherapy strategy and development of novel drugs.