我院52例对比剂引发的药品不良反应分析

Analysis of 52 Cases of Adverse Drug Reactions Induced by Contrast Media in Our Hospital

目的:分析我院由对比剂引发的药品不良反应(ADR)的特点,为降低造影检查的用药风险提供参考。方法:回顾我院近5年对比剂所引发的ADR,按对比剂品种,患者性别、年龄,ADR临床表现等进行统计分析。结果:调查期间我院共发生对比剂引发的ADR 52例,其中男16例,女36例,患者平均年龄为(56.8±13.0)岁,不良反应累及系统以皮肤及其附件的例数最多,对比剂的品种涉及非离子型碘对比剂碘佛醇、碘普罗胺、碘比醇及MRI对比剂钆喷酸葡胺,数量以碘普罗胺和碘佛醇为多。51例出现时间在注射后20 min内,1例出现在注射后60 min后。治愈5例,好转46例,死亡1例。结论:需重视对比剂引发的ADR,密切观察和积极干预可提高对比剂的用药安全性。

Objective：To analysis the characteristics of adverse drug reactions（ADR） induced by contrast media in Zhejiang Hospital, so as to provide a reference to reduce the risk of its use. Methods： We reviewed the cases of contrast media induced adverse drug reactions during enhanced examination in recent 5 years, described the relationships between the use of the agent and gender, age, clinical manifestation, and other factors respectively. Results：A total of 52 cases of adverse reactions were induced by contrast media, 16 patients were males and 36 patients were females, the average age was （56.8 ± 13.0） years old, ADR mainly occurred in skin and appendages disorders. Most of ADR were caused by nonionic iodine contrast media ioversol, iopromide, iobitridol mid magnetic resonance contrast media gadopentetate dimeglumine, ioversol and iopromide induced most of the reactions. 51 cases occurred within 20 minutes after injection, 1 case occurred after 60 minutes after injection. In 52 cases, 5 patients were cured, 46 patients were ameliorated, 1 patient was deceased. Conclusion： It is necessary to pay attention to adverse reactions induced by contrast media, close observa- tion and active intervention could improve the safety of using contrast media.