摘要
Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one(1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one(2). Compounds 1 and 2 were named as Juglanstetralone A(1) and Juglanstetralone B(2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 ?g?mL –1.
Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one（1）, 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one（2）. Compounds 1 and 2 were named as Juglanstetralone A（1） and Juglanstetralone B（2）. Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 ？g？mL –1.
基金
supported by Major National Drug Program(No.2010ZX09102-138)
the Innovation Fund for Youth Science and Technology in Harbin(No.2012RFQYS042)
关键词
药学
药剂学
调剂学
剂型
Juglanstetralone A Juglanstetralone B Walnut husk Juglans mandshurica Anticancer activity
