CD44在胰腺癌中的表达及其临床意义

Expression of CD44 of patients with pancreatic cancer and its clinical significance

目的探讨CD44在人类胰腺癌发生、发展中可能的作用以及与胰腺癌各临床病理参数、生存期和预后的关系。方法选取2010年1月—2012年12月在上海交通大学医学院附属新华医院胰腺癌手术标本共67例,记录患者性别、年龄、组织学分型、肿瘤所在部位和淋巴结转移等情况,采用免疫组织化学法检测CD44的表达。结果 CD44在67例胰腺癌阳性表达率为73.1%(49/67)。单因素分析显示,胰腺癌患者的T分期、TNM分期、淋巴结转移情况、分化程度、肿瘤部位与CD44的阳性率表达相关(P<0.05)。而年龄、性别、血管侵犯、神经侵犯等与CD44的阳性率表达差别无统计学意义(P>0.05)。Cox模型分析显示:分化程度、CD44的表达情况、神经侵犯可作为独立的预后因子。结论胰腺癌中CD44呈高表达,其与胰腺癌的恶性程度有关。分化程度、CD44的表达情况、神经侵犯为胰腺癌的独立预后因子。

Objective To investigate possible effects of CD44 on the incidence and development of human pancreatic caner and the correlations among CD44 and clinical pathological parameters,survival period,and prognosis of patients with pancreatic cancer.Methods A total of 67 pancreatic cancer samples were collected in Xinhua Hospital,Shanghai Jiao Tong University School of Medicine from Jan.2010 to Dec.2012.The gender,age,histological typing,location of tumor,and lymph node metastasis of patients were recorded and the expression of CD44 was detected by the immunohistochemical method.Results The positive rate of CD44 expression of 67 samples was 73.1%（49/67）.Univariate analysis showed that the positive expression of CD44 was correlated with T staging,TNM staging,lymph node metastasis,the differentiation degree,and location of tumor（P〈0.05）.The differences of the positive rate of CD44 expression of patients with different age,gender,vascular invasion,and nerve invasion were not statistically significant（P〉0.05）.The Cox proportional hazards model analysis showed that differentiation,C D44 expression,and nerve invasion were independent prognostic factors.Conclusion The expression level of CD44 of patients with pancreatic cancer was high and correlated with the malignant degree of pancreatic cancer.CD44 expression,differentiation,and nerve invasion are independent prognostic factors of pancreatic cancer.