精子鞭毛结构蛋白研究进展

Research advances of structural proteins of sperm flagella

精子鞭毛是成熟精子的动力器官,其基于微管的轴丝结构在进化过程中高度保守。精子鞭毛结构和功能相关蛋白质的缺陷或缺失,均会导致精子运动功能障碍,进而导致男性不育。该文对精子尾部形成及动力相关分子的最新研究进展进行综述,这类分子结构与功能的障碍与临床许多疾病息息相关。

The flagellum is the motility organ of mature sperms and its microtubule based axoneme structure is highly conservative during evolution.The defect or missing of sperm flagella protein,which is relevant to the structure and function of sperms,can lead to motility dysfunction of sperms and cause male infertility.This paper reviews the latest research advances of molecules relevant to the formation and motility of sperm tails.Problems of structure and function of these molecules are closely related to many clinical diseases.