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^1H—MRS对新生儿急性胆红素脑病和缺氧缺血性脑病的鉴别诊断价值 被引量：10

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摘要 目的探讨氢质子磁共振波谱(1H-MRS)对新生儿急性胆红素脑病(ABE)与缺氧缺血性脑病(HIE)的鉴别诊断价值。方法选取ABE患儿15例、HIE患儿16例,同时选取正常新生儿12人作为对照组,行头颅常规MRI及1H-MRS检查,对苍白球病变中心部位测定代谢产物N-乙酰天冬氨酸(NAA)、肌酸(Cr)、胆碱复合物(Cho)、乳酸(Lac)、谷氨酸及谷氨酰胺复合物(Glx)、肌醇(MI),计算NAA/Cr、Cho/Cr、Lac/Cr、Glx/Cr、MI/Cr比值,分析3组患儿脑内各代谢物浓度差异。结果 ABE组与HIE组的Lac/Cr分别为0.47±0.31和3.54±0.21,ABE组乳酸峰低平,HIE组乳酸峰明显升高,两组间差异有统计学意义(P<0.05);ABE组与HIE组的Glx/Cr均较对照组升高,且两组间差异有统计学意义;ABE组与HIE组的NAA/Cr较对照组降低,但两组间差异无统计学意义(P>0.05);Cho/Cr、MI/Cr在3组间均差异无统计学意义(P>0.05)。结论新生儿ABE和HIE均可表现为双侧苍白球T1WI高信号,1H-MRS可无创观察患儿病变区代谢情况,为其鉴别诊断提供重要信息。
作者 李金成 席艳丽
机构地区 吉林省长春市儿童医院放射科 南京医科大学附属南京儿童医院放射科
出处 《中国妇幼保健》 CAS 2015年第28期4912-4913,共2页 Maternal and Child Health Care of China
关键词 磁共振波谱 新生儿 急性胆红素脑病 缺氧缺血性脑病
分类号 R722 [医药卫生—儿科]
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参考文献6

  • 1Wu W, Zhang P, Wang X, et al. Usefulness of 1H-MRS in differentiating bilirubin encephalopathy from severe hyperbiliru- binemia in neonates [J]. J Magn Reson Imaging, 2013, 38 (3) : 634-640.
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二级参考文献16

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共引文献17

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二级引证文献55

中国妇幼保健
2015年 第28期

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