2010—2012年贵州省地方性氟中毒监测网络实验室尿氟检测质量分析

Quality analysis of urinary fluoride detection ability from 2010 to 2012 in Guizhou endemic fluorosis monitoring network laboratories

目的评价贵州省地方性氟中毒监测网络实验室的尿氟检测质量，促进质量控制水平的提高。方法2010—2012年．按照《尿中氟化物的测定离子选择电极法》，在贵州省地方性氟中毒监测网络的11个实验室进行质量控制考核。内部质量控制考核时，对标准物质进行平行样检测和人员及仪器比对检测，采用t检验比较组间差异．夕h部质量控制考核时，对尿氟盲样进行检测，采用Z比分值法评价，并比较检测结果的相对误差。结果在内部质量控制考核中，平行样检测和人员及仪器比对检测结果的差异均无统计学意义（t=-1．81～1．80。P均〉0．05）。在外部质量控制考核中，2010年，有1个实验室｜Z｜≥3，另10个实验室中有2个检测结果｜Z｜〉2；2011年，有4个实验室检测结果｜Z｜〉2；2012年，有5个实验室检测结果｜Z｜〉2。2010年，1个实验室的1个盲样检测结果相对误差〉20％，2011和2012年，均有1个实验室的1个盲样检测结果的相对误差〉10％。结论贵州省地方性氟中毒监测网络的实验室的检测能力相对较好，但是个别实验室存在明显的系统误差。

Objective To evaluate the urinary fluorine detection quality of endemic fluorosis monitoring network laboratories in Guizhou Province and promote the improvement of quality control. Methods From 2010 to 2012, according to the method for determination of fluoride in urine by ion selective electrode, in 11 endemic fluorosis monitoring network laboratories in Guizhou, an quality control assessment was done. In the internal quality control assessment, standard substance detection inspection was used for personnel parallel samples and equipment comparison, t test was used to compare the inter-group differences. In the external quality control inspection, blind urine fluorine sample was tested, and a Z score value evaluation method was used to compare the relative error of the test results. Results In the assessment of internal quality control, the parallel comparison test results of sample, personnel and instrument showed that the differences were not statistically significant （t = - 1.81 - 1.80, P 〉 0.05）. In 2010, in the external quality control inspection, there was 1 laboratory ｜Z｜≥3, and 2 test results ｜Z｜〉 2; in 2011, there was 4 test results ｜Z｜〉 2; in 2012, there was 5 test results ｜Z｜〉 2; in 2010, there was one laboratory in a blind test, relative error of the results 〉 20%; in 2011 and 2012, there was a laboratory in a blind test, relative error of the results 〉 10%. Conclusion The endemic fluorosis monitoring network laboratory testing ability in Guizhou is relatively good, but there is an obvious individual laboratory system error.