摘要
同型半胱氨酸（Hcy）已经证实是心血管疾病的独立危险因子，在各种病因导致的慢性肾脏病、不典型溶血尿毒综合征、甲基丙二酸尿症伴肾损伤的病例中，高同型半胱氨酸血症（HHcy）也是其突出的临床表现之一，而目前肾脏病学界对其导致的肾损伤认识尚不足。现对Hcy的合成、代谢，HHcy病因及导致心、肾损伤的发病机制，临床治疗现状等作一综述，以引起临床医师尤其是儿肾科医师的关注，提高临床综合诊治水平，改善心、肾病患儿的预后。
Homocysteine has been confirmed as the independent factor for cardiovascular disease. Hyperhomocysteinemia remains the prominent manifestation in the cases of chronic kidney disease, atypical hemolytic anemia, methylmalonie aciduria combined with kidney injuries. As the recognition of the kidney injuries caused by homocysteine remains obscure, this review tries to show the synthesis, metabolism of homocysteine and the possible mechanism of homocysteine - induced heart and kidney injuries. Besides, summarize the current treatment of lowering - hyperhomocysteinemia in order to arouse the pediatricians＇ attention of homocysteine which has endothelial cell toxicity and causes the wide lesions in great, middle and small vessels, and thus improve the outcomes of the patients.
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2015年第17期1355-1357,共3页
Chinese Journal of Applied Clinical Pediatrics
