复方血栓通口服联合激光光凝与单用激光光凝比较治疗糖尿病视网膜病变疗效的Meta分析

Effect of Fufang Xueshuantong Combined with Laser Photocoagulation versus Laser Photocoagulation Along for the Treatment of Diabetic Retinopathy: A Meta-analysis

目的系统评价复方血栓通口服联合激光光凝(光凝)与单用光凝比较治疗糖尿病视网膜病变的疗效。方法计算机检索Web of Science、Medline、Embase、Cochrane图书馆、中国生物医学文献数据库、维普数据库、中国期刊全文数据库、万方数据库,检索时限均从建库起截止2015年6月,根据Cochrane系统评价方法对纳入的随机对照试验进行方法学质量评价,并用Rev Man 5.2软件进行Meta分析。结果共纳入8个随机对照试验,695例患者。Meta分析结果显示,复方血栓通+光凝+常规治疗组在视力变化[RR=1.19,95%CI(1.12,1.26),P<0.000 01]、眼底变化[RR=1.34,95%CI(1.18,1.52),P<0.000 01]、黄斑水肿消退情况[RR=1.29,95%CI(1.09,1.54),P=0.004]等方面疗效均优于光凝+常规治疗组,且差异有统计学意义。结论复方血栓通口服联合光凝疗效优于单用光凝,但纳入试验质量较低,该结论还需高质量、大样本研究进一步验证。

Objective To evaluate the effects of Fufang Xueshuantong combined with laser photocoagulation versus laser photocoagulation alone in the treatment of diabetic retinopathy （DR）. Methods The Web of Science, Medline, Embase, the Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, VIP and Wanfang databases were searched from their establishment until June 2015. We used the method recommended by the Cochrane Collaboration to perform a meta-analysis of randomized controlled trails. RevMan 5.2 software was used for the analysis. Results Eight studies were included, The results of Meta-analysis demonstrated that Fufang Xueshuantong combined with laser photocoagulation was superior to laser photocoagulation alone in the effective rate of visual acuity [RR=1.19, 95%CI （1.12, 1.26）, P 〈 0.000 01], fundus [RR=1.34, 95%CI （1.18, 1.52）, P 〈 0.000 01], and elimination rate of macular edema [RR=1.29, 95%CI （ 1.09, 1.54）, P=0.004], Conclusions Fufang Xueshuantong combined with laser photocoagulation is effective for DR. However, due to the limited quantity and quality of the included studies, the results suggest that larger-scale trials are needed.