不同病情闭塞性细支气管炎患儿临床特征比较

Comparison of clinical features of children with bronchiolitis obliterans of different severity

目的比较病情轻重程度不同的闭塞性细支气管炎(BO)患儿临床表现,总结二者差异。方法收集北京儿童医院2001年4月至2012年4月临床诊断为BO的147例患儿病情资料。根据其病情轻重进行分组,重症组44例,轻症组103例。比较并分析不同病情患儿在肺功能、肺高分辨率CT(HRCT)表现及预后方面的差异。结果重症组年龄分布中位数为14个月,轻症组年龄分布中位数为24个月,差异具有统计学意义。HRCT支气管扩张征象,重症组为70.50%,轻症组为47.60%,差异具有统计学意义。重症组达峰时间比(t PTEF/t E)、达峰容积比(VPTEF/VE)、吸气时间/呼气时间(Ti/Te)较轻症组低,差异有统计学意义。重症组中期流速比(TEF50/TIF50)较轻症组低,差异有统计学意义。重症组呼吸系统阻力(Rrs)较轻症组高,差异有统计学意义。死亡病例均为重症组。结论重症病例患儿年龄偏小,肺高分辨CT支气管扩张比例较高,小气道功能差,预后较差。

Objective To find differences of clinical characteristics between severe group and mild group in children with bronchiolitis obliterans. Methods 147 cases of bronchiolitis obliterans were summarized in children diagnosed in Beijing Children＇s Hospital from April 2001 to April 2012. The 147 cases were divided into 2 different groups according to their clinical severity and tried to find the differences of their lung function, CT findings and prognosis. Results The 147 cases were divided into 2 different groups, according to their clinical severity. Compared with mild group, the severe group was younger, with more bronchiectasis in HRCT and worse airway function. Four dead cases were all in severe group. Conclusion The severe group has small age, more bronchiectasis in HRCT and worse airway function.