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一株分离自黑果枸杞的内生真菌米曲霉代谢产物(英文) 被引量:2

Metabolites of Aspergillus oryzae,an Endophytic Fungus Associated with Lycium ruthenicum Murr.
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摘要 从黑果枸杞内生真菌米曲霉RER4的发酵物中分离出9个化合物,通过波谱技术分别鉴定为麦角甾醇(1)、5-羟基-苯并呋喃-2(3H)-酮(2)、2,5-二羟基苯乙酸甲酯(3)、5-羟甲基呋喃-3-甲酸(4)、pyranonigrins A(5)、campyrones A(6)、4-乙酰氨基丁酸(7)、rubrofusarin B(8)以及asperpyrones A(9),其中化合物2~9为首次从米曲霉发酵物中分离出。抗氧化活性测试表明:化合物2和3对DPPH自由基抑制率的IC50值分别为4.58和7.00μg/m L。这些化合物对四株细菌(大肠杆菌、绿脓杆菌、金黄色葡萄球菌、枯草芽孢杆菌)和四株植物病原真菌(尖孢镰刀菌、小麦赤霉病菌、苹果树腐烂病菌、番茄灰霉病菌)的生长表现出不同程度的抑制作用。 Nine known compounds were isolated from Aspergillus oryzae RER4, and their structures were elucidated as er- gosterol ( 1 ), 5 -hydroxy-benzofuran-2 (3H) -one ( 2 ), 2,5 -dl -hydroxyphenyl acetate ( 3 ), 5-hydroxymethylfuran-3- car- boxylic acid (4) ,pyranonigrins A (5) ,campyrones A (6) ,4-acetamidobutanoic acid (7) ,rubrofusarin B (8) and as- perpyrones A (9) by comprehensive spectral analysis. Compound 2-9 were isolated from the culture of A. oryzae for the first time. The DPPH mdieal-scavenglng activity assays showed that compounds 2 and 3 had potential activity with ICso of 4.58 and 7.00 p@/mL, respectively. In the antimicrobial activity test for four bacteria (E. coli,P, aeruginosa,S, aureu, B. subtilis) and four fungi( F. oxysporium , G. . saubinerii , C. mandshurica , B. cirerea ) , all compounds exhibited a wide inhibition to bacterial and fungal growth.
出处 《天然产物研究与开发》 CAS CSCD 北大核心 2015年第9期1554-1557,共4页 Natural Product Research and Development
基金 The Specialized Research Fund for the Doctoral Program of Higher Education(20116125110001) The Natural Science Basic Research Plan in Shaanxi(2014JZ003)
关键词 内生真菌 黑果枸杞 代谢产物 生物活性 endophytic fungus Lycium ruthenicum Murr metabolites bioactivities
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