潍坊市手足口病患者柯萨奇病毒A16型感染分析

Analysis of pathogenic characteristics of Coxsackie virus A16 of HFMD patients in Weifang

目的了解潍坊市2013-2014年引起手足口病(实验室确诊)的病原体柯萨奇病毒A16型(CA16)的流行状况,从而制定更良好的预防措施,降低发病率。方法采用实时荧光定量法对2013-2014年潍坊市所辖的16个县市上送的共1318例手足口病患者粪便标本进行核酸检测,并从地域、年龄、性别、职业、病例性质等角度对结果进行分析。结果 2013年实验室确诊203例CA16阳性标本,2014年为152例,发病地域以中西部居多,男童多于女童,两年男女发病比例分别为1.67:1及1.76:1,3岁以下散居幼童居多,病例性质上普通病例占绝大多数,重症最少,分别为2例及3例。结论加大宣传力度,强化控制措施,尤其对3岁以下散居幼儿家庭,有利于更好地控制由CA16引起的感染,降低发病率。

Objective To investigate the in Weifang City 2013-2014 caused the prevalence of hand, foot and mouth disease （laboratory confirmed） pathogen coxsackievirus A16 （CA16）, to develop more good preventive measures, to reduce the rate of incidence of a disease. Methods By real-time fluorescence quantitative PCR in 2013-2014 Weifang City under the jurisdiction of the 16 counties and cities to send a total of 1 318 cases of HFMD stool specimens of patients with nucleic acid detection, and analyses the results from the perspective of the region, age, sex, occupation, case properties. Results 2013 laboratory confirmed 203 cases CA 16 positive samples, 152 cases in 2014, incidence area mostly in the Midwest, more boys than girls, two years in male and female incidence ratio respectively 1.67 ： 1 and 1.76 ： 1, 3 years old of the following scattered children dominated, case properties of ordinary cases accounted for the vast majority of, the least severe, respectively in 2 cases and 3 cases.Conclusions To increase publicity efforts, the enhanced control measures, especially of 3 years old of the following scattered children family, to better control by CA16 infection, to reduce the rate of incidence of a disease.