聚团肠杆菌感染分布与耐药性分析

Distribution and drug resistance of Enterobacter agglomerans

目的了解聚团肠杆菌的分布与耐药性,为临床提供参考依据。方法药物敏感性检测采用纸片扩散(K-B)法,用WHONET 5.6软件统计分析。结果 2011年6月至2014年7月临床患者标本中分离的聚团肠杆菌65株,普外科分离出17株,占26.15%,检出率最高,其次为骨外科、泌尿外科、儿科,分别分离出13株、10株、9株,各占20.00%、15.38%、13.64%;以肺部和创面感染较常见,分别占40.91%、27.27%。聚团肠杆菌对头孢唑林、四环素、氨苄西林、头孢噻肟、庆大霉素等常用抗菌药物的耐药率较高分别为81.82%、63.64%、88.24%、66.67%、58.82%等,仅对哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、美罗培南、亚胺培南等较敏感,耐药率分别为7.14%、5.56%、0.00%、0.00%。结论聚团肠杆菌的耐药性已较为严重,表现为对多药耐药,呈重耐药性,仅对含有β-内酰胺酶抑制剂的头孢哌酮/舒巴坦和哌拉西林/他唑巴坦及碳青霉烯类抗菌药物美罗培南、亚胺培南耐药率较胝。

Objective To learn the distribution and drug resistance of Enterobacter agglomerans,and provide reference for clinical use of antibiotics. Methods Drug susceptibility test was conducted by using disk diffusion（ K-B）method; WHONET 5. 6 software was used for statistical analysis. Results Of the total 65 strains of Enterobacter agglomerans clinically isolated from June 2011 to 2014 July,17 strains（ 26. 15%） were from the general surgery department,13 strains（ 20. 00%） were from the orthopedic surgery department,10 strains（ 15. 38%） from the urology department,and 9 strains（ 13. 64%） from the pediatrics department. Wound infection and lung infection were the more common,accounting for 40. 91% and 27. 27%,respectively. The resistance rate of Enterobacter agglomerans was 81. 82% to Cefazolin,68. 64% to Tetracycline,88. 24% to Ampicillin,66. 67% to Cefotaxime,and 58. 82% to Gentamicin,while the resistance rates to Piperacillin / Tazobactam,Cefoperazone / Sulbactam,Meropenem and Imipenems were 7. 14%,5. 56%,0. 00% and 0. 00%,respectively. Conclusion Enterobacter agglomerans is highly resistant to many antibacterial drugs with multiple resistance,while its resistance rates to Cefoperazone / Sulbactam,Piperacillin / Tazobactam,Meropenem and Imipenem are lower.