肺癌铂类化疗所致周围神经毒性与SNP相关性研究

Correlation between SNP and platinum-induced peripheral neurotoxicity in lung cancer

目前肺癌发病率与死亡率均居恶性肿瘤首位,铂类药物已广泛应用于肺癌等多种癌症的治疗。然而,铂类药物化疗取得较佳疗效的同时,往往由于严重的毒副反应而限制了其使用剂量,从而难以达到最佳疗效。其中,铂类药物化疗所引起的周围神经毒性(peripheral neurotoxicity,PN)十分常见。与此同时,临床中周围神经毒性的发生存在较大的个体性差异,其药物代谢相关基因的单核苷酸多态性(single nucleotide polymorphism,SNP)的遗传变异可能是引起PN发生个体差异的重要原因之一。本文就DNA修复酶、药物代谢酶、转运体等相关基因的SNP与铂类化疗引起的PN之间的相关性作一综述。

In general,both the incidence and mortality of lung cancer are the highest among all malignant tumors.Platinum drugs have been widely used for the treatment of lung cancer and other cancers. However,although effective,since it usually causes acute toxicity,the dose of platinum is limited,and it is difficult to achieve the best curative effect. Peripheral neurotoxicity（ PN） induced by platinum drugs is common. At the same time,there are individual differences in the incidence of peripheral neurotoxicity among patients. The variation of single nucleotide polymorphism（ SNP） of the drug metabolism-associated gene may be one of the important reasons. In this review,the correlations between platinum-induced PN and the SNPs of DNA repair enzyme,drug metabolizing enzymes,transporters and other related genes were discussed.