甘草及其有效成分抗脂肪肝和抗肥胖的研究进展

Research advances on anti-obesity and anti-fatty liver effects of licorice and its active components

甘草具有抗脂肪肝和抗肥胖的药理作用,甘草黄酮类化合物和甘草酸类化合物是其有效成分。甘草及其有效成分通过它们的抗氧化作用、活化过氧化物酶体增殖子激活型受体,抑制蛋白酪氨酸磷酸酶1B或Ι型11β-羟基甾体脱氢酶或1型大麻素受体,上调与脂肪酸β-氧化有关的基因表达,下调与脂肪生成有关的基因表达,解除胰岛素抵抗和改善脂代谢、糖代谢紊乱,产生抗脂肪肝和减肥作用。临床上已将甘草酸类化合物试用于脂肪肝的治疗,且取得了较好疗效。综述了甘草及其有效成分抗脂肪肝和抗肥胖作用的研究进展,为抗代谢综合征新药的研发提供依据。

Licorice has the effects of anti-obesity and anti-fatty liver. Licorice flavonoids and glycyrrhizic acid derivatives are its active components. Licorice and its active components improve carbohydrate and lipid metabolic disorders, and insulin resistance to produce the effects of anti-obesity and anti-fatty liver by anti-oxidation, activation of PPAR, inhibition of PTP 1 B or 11β-HSD 1 or CB 1 R to up-regulate the expression of fatty acid D-oxidation-related genes, and to down-regulate the expression of adiogenesis-related genes. In clinic glycyrrhizic acid derivatives have been used to treat for fatty liver, and their clinical efficacy have been proved. This paper reviews the research progress in anti-obesity and anti-fatty liver effects of licorice and its active components to provide the basis for research and development on new drug against metabolism syndrome.