冬虫夏草抗肿瘤及免疫调节作用的研究进展

Progress in studies on antitumor and immunomodulatory effect of Cordyceps sinensis

冬虫夏草为我国传统名贵中药,具有抗肿瘤、降血脂、免疫调节、祛痰、平喘、抗心律失常、保护肝肾功能等多种药理学作用。随着对冬虫夏草免疫机制的深入研究,为其作为抗肿瘤药物提供了有力证据。综述了冬虫夏草及其活性成分对黑色素瘤、甲状腺癌、胃癌、肺癌、乳腺癌等多种肿瘤的抑制作用,主要从吞噬细胞、自然杀伤细胞、树突状细胞、B/T淋巴细胞以及促进细胞因子的分泌等几个方面探讨冬虫夏草对其免疫活性的影响。其免疫调节的作用机制主要通过T淋巴细胞介导的细胞免疫应答和B/T淋巴细胞介导的体液免疫应答。

Cordyceps sinensis as a traditional Chinese herbal medicine, has a variety of pharmacological effects of anti-tumor, reducing blood lipid, immune regulation, eliminating phlegm, relieving asthma, anti-arrhythmic, protecting liver and kidney, and so on.With the further research of immunological mechanism, C. sinensis has been considered as a potential candidate of anti-tumor drug. In this paper, amount of experiments data and clinical trials indicated the chemical constituents from C. sinensis have the significant inhibition on a variety of tumors, such as melanoma, thyroid cancer, gastric cancer, lung cancer, breast cancer, and other tumors. The strong anti-tumor activities support the interpretation of immunoregulatory mechanism of C. sinensis, which could activate T-lymphocyte cellular immune response and B/T lymphocyte-mediated humoral immune response. Our paper summarized the immune responses of the components from C. sinensis by macrophages, nature killer cells, dendritic cells, B/T lymphocytes and cytokines.