建立胚胎与子宫内膜相互作用体外模型的研究进展

Research progress on in vitro model for the study of embryo and endometrium interactions

胚胎与子宫内膜协调合作对胚胎正常着床至关重要。由于伦理与法律的限制,胚胎着床相关机制的研究进展缓慢,尽管已有许多动物体内实验,但是其研究结果并不能完全应用于人类。近几年来,体外模型的建立给我们提供了一个新的途径。本文将研究胚胎与子宫内膜相互作用的体外模型分为三类,包括二维模型、三维模型以及迁移与侵袭实验模型。这些模型不仅可以用来研究胚胎-子宫内膜在早期着床位点的对话及其分子机制,还可以用来研究早期胚胎发育的过程和生殖内分泌紊乱的病理生理机制。

The coordination between embryos and endometrium is essential to the normal embryo implantation. Some animal models have been used to study the embryo implantation, but the results could not be fully applied to human. In recent years, in vitro model provides us with a new approach. In this article, the in vitro model is divided into three categories, including 2D model, 3D model and the migration and invasion model. These models can not only be used to study the embryo-endometrial dialogue at the implantation sites in the early stages of implantation, but can also be used to study the early embryonic development and the pathophysiology of reproduc- tive endocrine disorder.