晚期糖基化终产物在女性生殖中的研究进展

Research progress of advanced glycation and products in female reproduction

晚期糖基化终产物(advanced glycation end products,AGEs)是体内蛋白质与还原糖在无酶条件下发生反应后的产物。AGEs与机体衰老密切相关,病理情况下AGEs通过直接影响卵巢功能,以及通过参与多囊卵巢综合征(PCOS)、子宫内膜异位症(EMs)的发生发展,对女性生殖产生重要影响。

Advanced glycation end-products （AGEs） are reactive cross-linked molecules tbrmed by non- enzymatic reactions of reducing sugars with amino groups of proteins, lipids or nucleic acids. Formation and accumulation of AGE occurs during normal aging. AGEs not only participates in the development of ovary dysfunction, but also in closely related to polycystic ovary syndrome （PCOS）, endometriosis （EMs）, and be proposed to play an important role in diminished female reproduction.