2011—2012年福建省新发成人急性白血病发病情况调查

Incidence of newly diagnosed adult acute leukemia in Fujian province from 2011 to 2012

目的在2010年调查基础上，了解2011-2012年福建省新发成人急性白血病发病情况。方法通过收集福建省医学会血液病学分会临床协作组的各级医院填报统一的登记表，回顾性分析2011-2012年新诊断、年龄914岁的成人急性白血病的发病情况。结果①2011-2012年福建省新发成人急性白血病患者共1551例，平均年发病率为2．479／10万。2011年新发病例为777例，粗发病率为2．498／10万，年龄标化发病率为2．504／10万；2012年新发病例为774例，粗发病率为2．460／10万，年龄标化发病率为2．455／10万。2年标化发病率比较无明显变化。②急性髓系白血病[AML，非急性早幼粒细胞白血病（APL）]发病率为1．499／10万；急性淋巴细胞白血病（ALL）发病率为0．628／10万；APL发病率为0．318／10万；特殊类型急性白血病发病率为0．034／10万。AML（非APL）发病率最高（占60．48％），其次为ALL（25．34％）、APL（12．83％），特殊类型（1．35％）最少见。③福建省急性白血病发病有性别、年龄、地区和季节差异。AML、ALL男性发病率高于女性。2011—2012年福建省急性白血病发病率随年龄增长而增加，发病率高峰出现在75-79岁，发病率为7．081／10万。结论结合国际癌症研究机构（IARc）提供的我国白血病发病率数据，2011-2012年福建省成人急性白血病发病率在国内处于一般水平，略高于1986—1988年全国急性白血病发病率。2011-2012年的发病趋势无明显变化。各类型成人急性白血病的构成情况与全国基本一致。

Objective To investigate the incidence of adult （≥14-year-old） acute leukemia（AL） in Fujian Province from 2011 to 2012, based on the survey in 2010. Methods All newly diagnosed adult AL cases were collected during 2011 and 2012 retrospectively, which were registered identically by the clinical collaborative group of Fujian Medical Association Hematological Branch. The group included all the hospitals that could diagnose leukemia. Results ①We registered 1 551 new adult AL cases totally during 2011 and 2012. The average annual incidence was 2.479/10^5. 777 new adult AL cases were diagnosed among the whole adult population in Fujian Province in 2011.The crude incidence rate （CIR） was 2.498/105, and age-standardized incidence rate （ASR） was 2.504/105. 774 new adult AL cases were diagnosed in 2012 with 2.460/105 of CIR and 2.455/105 of ASR. No significant changes of the adult AL incidence were found over time during 2011 and 2012. ②During 2011 and 2012, 938 cases of acute myeloid leukemia （AML, non-M3） were diagnosed,with 1.499/105 of CIR. 393 cases of acute myeloid leukemia（ALL） with 0.628/105 of CIR, 199 cases of acute promyeloeytic leukemia（APL） with 0.318/105 of CIR, 21 cases of the special type with 0.034/105 of CIR. The incidence of AML （non-M3） was highest （accounting for 60.48% ）, followed by ALL （25.34%）, APL （ 12.83% ）. The special type （ 1.35% ） was the lowest. ③The survey revealed differences in gender, age, region and season of incidence in Fujian province. The male gender bias of AML and ALL were also observed. The incidence of adult AL increased with age, and reached to the peak in group aged 75-79 （7.081/10s）. Conclusion The incidence of adult AL in Fujian province is in average level in China from 2011 to 2012, according to the leukemia incidence data of International Agency for Research on Cancer （IARC）. Compared with the previous national leukemia incidence during 1986 and 1988, the incidence in Fujian is slightly higher. We find no significant changes of the incidence from 2011 to 2012. The constituent ratios of various types of adult AL in Fujian are similar to the previous studies of national incidence rate during 1986-1988.