柴黄汤联合西药治疗重症急性胰腺炎48例临床观察

Clinical Observation of Using Chaihuang Decoction Combined with Western Medicine to Treat 48 Cases of Severe Acute Pancreatitis

目的：重点研究柴黄汤与西药治疗重症急性胰腺炎的临床疗效,以提供数据供内科保守治疗参考。方法：对2011年10月~2013年12月我院入院治疗的96例重症胰腺炎患者进行了详细的研究,将这些患者随机分为两组,对照组的患者给予常规的西药治疗,比如胃肠检验、禁食、补充体液、纠正电解质及酸碱失衡、抗感染治疗等等,观察组患者在上述常规西药治疗基础上,同时给予自拟柴黄汤,两组治疗方案都以14天为1个疗程。结果：经过研究,观察组患者肝脏相关指标的改善情况明显好于对照组,转氨酶的水平明显降低,两组比较差异有统计学意义（P〈0.05）;观察组患者的腹胀或腹痛、肠鸣音等临床症状的改善时间明显短于对照组,患者体温、淀粉酶恢复至正常时间以及住院的时间明显少于对照组,差异有统计学意义（P〈0.05）;经过2周的治疗,观察组组患者治疗后的APACHE II评分明显低于对照组患者对应的评分,差异有统计学意义（P〈0.05）;观察组患者的临床总有效率可达93.8%,这个数据明显高于对照组68.8%的总有效率,两组比较差异明显,有统计学意义（P〈0.05）。结论：柴黄汤联合西药治疗重症急性胰腺炎的临床效果非常明显,能够更明显的改善患者临床症状及肝脏指标,临床应答率更高,值得在临床治疗中推广应用。

Objective ： To study the clinical curative effect of using Chiahuang Decoction and western medicine in the treat- ment of severe acute pancreatitis, in order to provide reference data for the conservative treatment of internal medicine. Methods ： 96 cases of patients with severe acute pancreatitis from October 2011- December 2013 in our hospital were admitted to the hospi- tal were studied in detail, these patients were randomly divided into two groups, the controlled group were given conventional western medicine treatment, such as gastrointestinal examination, fasting, fluid supplement, correct electrolyte and acid-base imbalance, anti-infection treatment, the observed group was treated with Chaihuang Decoction on the basis of the controlled group at the same time, 2 N 14 days for a course of treatment. Results ： After the study, improvement of the situation of the observed group of patients with liver was significantly better than the controlled group, ALT and AST levels were significantly lower, the difference between the two groups was statistically significant （ P〈0. 05 ） ; the observation group of patients with abdominal pain or abdominal distention, bowel sounds and other clinical symptoms improved time significantly shorter than the controlled group, the body temperature of patients, amylase returned to normal time and hospitalization time were significantly less than the controlled group, the difference was statistically significant （P〈0. 05） ; after two weeks of treatment, group APACHE patients after treatment II score was significantly lower than the controlled group patients were observed corresponding to the score, the difference was statistically significant （ P〈0. 05 ） ; the total effective rate of the observation group was up to 93. 8%, this data was significantly higher than the controlled group which was 68. 8%, the difference between the two groups was statistically significant （P〈0. 05）. Conclusion： The clinical effect of Chaihuang Decoction combined with western medicine in the treatment of severe acute pancreatitis is very obvious, can be more obvious improvement of clinical symptoms and liver index of patients, the clinical response rate is higher, it is worthy of popularization and application in clinical treatment.