医学防治对乙肝病毒携带者子女HBV感染状况的影响

Effect of Medical Prevention on HBV Infection in Children of Hepatitis B Virus Carriers

目的探讨医学防治对于乙肝病毒携带者子女HBV感染状况的影响。方法收集2009年4月~2014年4月经医学防治（121人）和未经医学防治（122人）的患者,均对他们做乙肝五项指标定性检测。结果经过医学防治的乙肝病毒携带者子女HBV感染率低于未经过医学防治者,大部分经医学防治的HBV携带者子女产生了保护性抗体。结论乙肝病毒携带者经抗病毒治疗后,能降低其体内血液中的HBVDNA含量,并且绝大多数能转阴;其子女出生后12 h内尽快接种乙肝疫苗、注射乙肝免疫球蛋白,可有效阻止母婴间的HBV感染。

Objective To investigate the effect of medical prevention on the HBV infection in children of HBV carriers.MethodsColected from April 2009 to April 2014 medical treatment（121）patients and without medical treatment（122）patients,and tested five indicators of hepatitis B virus.Results The rate of HBV infection in the children with hepatitis B virus carriers was significantly lower than that without medical treatment,and most of them had protective antibodies against HBV carriers. ConclusionHepatitis B virus carriers after antiviral therap,significantly reduced the HBV-DNA content in the blood,and most can be negative. The children within 12 hours after birth vaccinated the hepatitis B vaccine as soon as possible,and inject hepatitis B immunoglobulin protein,can effectively prevent mother to infant HBV infection.