探讨小剂量托吡酯联合奥卡西平治疗小儿癫痫的临床效果

The Clinical Effect of Small Dose of Topiramate and Oxcarbazepine in the Treatment of Pediatric Epilepsy

目的探讨分析小剂量托吡酯联合奥卡西平治疗小儿癫痫的临床效果。方法小儿癫痫患者120例,随机分为治疗组(60例)和对照组(60例),所有患儿均给予奥卡西平,对照组服用常规剂量托吡酯,而治疗组服用小剂量托吡酯。结果治疗组住院时间、治疗时间少于对照组(P<0.05);临床总有效率95%高于对照组80%(P<0.05);不良反应人数少于对照组(P<0.05)。结论小剂量托吡酯联合奥卡西平治疗小儿癫痫能够缩短治疗时间,提高临床有效率,安全可靠。

ObjectiveTo study the clinical effect of smal dose of topiramate and oxcarbazepine in the treatment of pediatric epilepsy. Methods 120 cases of pediatric epilepsy patients,randomly divided into treatment group（60 cases）and control group（60 cases）. Al children were given oxcarbazepine and topiramate,the control group took regular doses of topiramate,and the treatment group taking smal doses of topiramate. ResultsThe treatment group in the time length of hospital stay was less than the control group（P〈 0.05）. The clinical total effective rate was 95% was higher than the control group 80%（P〈 0.05）. Number of adverse reaction waslower than the control group（P〈 0.05）.Conclusion Smal dose of topiramate joint oxcarbazepine in treatment of pediatric epilepsy can significantly shorten the treatment time,improve clinical effective,and was safe and reliable.