二甲双胍片标准化包装调研

Research on the Standardized Package of Metformin Tablets

目的：探索满足临床需求的二甲双胍片标准化包装。方法：对全国6个城市医疗卫生机构二甲双胍片的使用数据进行统计;设计调查问卷,对北京、海口两地医师、药师、患者在处方、调配、使用环节对于二甲双胍片不同包装装量适宜度的评价进行调查和分析。结果：0.5 g/片二甲双胍片的日剂量分布中,以1.5 g在除成都以外的5个城市所占比例最大（32.23%～69.91%）。二甲双胍片的包装装量适宜度的问卷调查共发放问卷490份,回收有效问卷478份,有效回收率为97.5%。结果显示,北京医师、药师、患者均认为4周左右的包装装量适宜;而海口医师、药师、患者则认为1～2周的包装装量适宜;对于与自动摆药机的匹配度,两地药师均认为300～500片/瓶的包装装量适宜。结论：综合考虑两地的调研结果,对于0.5 g/片二甲双胍片,将门诊的包装装量规范为2周用量为宜,即0.5 g×45片/盒;住院药房以300～500片/瓶的包装装量为宜。

OBJECTIVE： To explore the standardized package of Metformin tablets to meet clinical needs. METHODS： Statis- tics was conducted for the utilization data of Metformin tablets in medical and health institutions from 6 cities of China; question- naires were designed to investigate and analyze the evaluation for the suitability of physicians, pharmacists and patients in the pre- scription, deployment and use links to Metformin tablets with different packaging loaded amount in Beijing and Haikou. RE- SULTS： For 0.5 g/tablet, the daily dose of 1.5 g accounted for the largest proportion （32.23%-69.91%） in 5 cities except for Chengdu. Totally 490 questionnaires about package suitability of Metformin tablets in outpatient department were sent out, includ- ing 478 valid questionnaires with effective rate of 97.5%. Results showed that packaging quantity with 4 weeks was considered as appropriate by physicians, pharmacists and patients in Beijing; however, packaging quantity with 1-2 week（s） was considered as appropriate by physicians, pharmacists and patients in Haikou; 300-500 tablets of packaging quantity were preferred to be appropri- ate with the matching degree of automatic dispensing machines in both places. CONCLUSIONS; Considering the results in 2 plac- es, for 0.5 g/tablet, 2 weeks is appropriate for the packaging loaded amount in outpatient department, that is 0.5 g×45 tablets/box; and 300-500 tablets/box is appropriate for inpatient pharmacies.