匹多莫德联合曲安奈德治疗口腔扁平苔藓的临床观察

Clinical Observation of Pidotimod Combined with Triamcinolone Acetonide in the Treatment of Oral Lichen Planus

目的:观察匹多莫德联合曲安奈德治疗口腔扁平苔藓的疗效和安全性。方法:回顾性分析60例口腔扁平苔藓患者资料,按用药的不同分为观察组(35例)和对照组(25例)。对照组患者给予曲安奈德注射液1 ml+2%利多卡因注射液1 ml混合,根据病损大小在局部病损区涂擦,3次/日;观察组患者在对照组治疗的基础上给予匹多莫德分散片800 mg,两餐间服用,2次/日,连用2周后,改为800 mg,口服,1次/日。两组患者疗效均为4周。观察两组患者的临床疗效,并随访用药1、3个月后的疗效及不良反应发生情况。结果:治疗1、3个月后,观察组患者总有效率均显著高于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论 :匹多莫德联合曲安奈德治疗口腔扁平苔藓较单用曲安奈德疗效更显著,安全性较好。

OBJECTIVE： To observe the efficacy and safety of pidotimod combined with triamcinolone acetonide in the treat- ment of oral lichen planus （OLP）. METHODS： Data of 60 patients with OLP were retrospectively analyzed and divided into obser- vation group （35 cases） and control group （25 cases） by different medication. Control group was treated with triamcinolone aceton- ide 1 m1＋2% Lidocaine injection 1 ml, embrocated in the local lesion area according to lesion size, 3 times a day; observatioh group was additionally treated with Pidotimod dispersible tablets 800 mg between meals based on the treatment of control group, twice a day, and then changed to 800 mg, orally, once a day after 2 weeks. The treatment course was 4 weeks. The clinical effica- cy and incidence of adverse reactions in 2 groups were observed. RESULTS： After 1 and 3 month（s）, the total effective rates in ob- servation group were significantly higher than control group, the difference was statistically significant（P〈0.05）. There was no sig- nificant difference in the incidence of adverse reactions between 2 groups （P〉0.05）. CONCLUSIONS： Pidotimod combined with triamcinolone acetonide has significant efficacy in the treatment of OLP, with good safety.