盐酸米诺环素联合替硝唑治疗慢性牙周炎的临床观察

Clinical Observation of Minocycline Hydrochloride Combined with Tinidazole in the Treatment of Chronic Periodontis

目的:观察盐酸米诺环素联合替硝唑治疗慢性牙周炎的疗效和安全性。方法:100例慢性牙周炎患者随机均分为观察1组、观察2组、观察3组和对照组。对照组患者均给予龈上洁治、龈下刮治后,用0.9%氯化钠注射液和3%过氧化氢交替冲洗牙周袋底部;在此基础上,观察1组患者患牙隔湿、干燥后,缓慢注射盐酸米诺环素软膏深入牙周袋底部,至略有溢出,1次/周;观察2组患者给予替硝唑口腔贴片1片贴敷于患牙颊侧正中牙龈表面,2次/天;观察3组患者给予盐酸米诺环素软膏+替硝唑口腔贴片(用法用量同上述两组)。各组患者疗程均为4周。观察各组患者的临床疗效,治疗前后全口牙菌斑指数(PLI)、牙周附着水平(PAL)、牙周袋深度(PPD)、牙齿松动度(MD)、牙龈出血指数(GI)及不良反应发生情况。结果:观察3组患者总有效率>观察1组和观察2组>对照组,差异均有统计学意义(P<0.05),但观察1组、观察2组两组间比较,差异无统计学意义(P>0.05)。治疗后,各组患者PLI、PAL、PPD、MD、GI均显著低于同组治疗前,且观察3组<观察1组和观察2组<对照组,差异均有统计学意义(P<0.05),但观察1组、观察2组两组间比较,差异均无统计学意义(P>0.05)。各组患者治疗期间均未见明显不良反应发生。结论:盐酸米诺环素联合替硝唑治疗慢性牙周炎较单用盐酸米诺环素或替硝唑疗效更显著,安全性较好。

OBJECTIVE： To observe the efficacy and safety of minocycline hydrochloride combined with tinidazole in the treat- ment of chronic periodontitis. METHODS： 100 patients with chronic periodontitis were randomly divided into observation group 1, observation group 2, observation group 3 and control group. Patients in control group were given full-mouth dental scalers and sub- gingival clean scraping, then 0.9% Sodium chloride injection and 3% hydrogen peroxide were used to alternately wash periodontal pocket bottom. Based on the treatment, observation group 1 was injected Minocycline hydrochloride ointment to periodontal pocket bottom until slight overflow after saliva isolation and desiccation, once a week; observation group 2 was given Tinidazole buccal tablet 1 tablet in the buccal middle gingival surface, twice a day, observation group 3 was given Minocycline hydrochloride oint- ment＋Tinidazole buccal tablets （the usage and dosage was the same with above-mentioned 2 groups）. The treatment course was 4 weeks. The clinical efficacy, PLI, PAL, PPD, MD, GI before and after treatment and incidence of adverse reactions were observed. RESULTS： The total effective rate in observation group 3 〉observation group 1 and observation group 2 〉control group （P〈0.05）, however, there was no significant difference between observation group 1 and observation group 2 （P〉0.05）. After treatment, PLI, PAL, PPD, MD and GI in all groups were significantly lower than before, and observation group 3〈than observation group 1 and observation group 2〈control group（P〈0.05） , however, there was no significant difference between observation group 1 and observation group 2 （P〉0.05）. There were no obvious adverse reactions during treatment. CONCLUSIONS： Minocycline hy- drochloride combined with tinidazole has better efficacy than minocycline hydrochloride or tinidazole in the treatment of chronic periodontitis, with good safety.