可降解镁合金作为骨填充材料的研究和展望

Research and Prospects of Mg-Based Metals as Bone Graft Substitutes

由于各种原因造成的骨缺损的修复是临床上一项具有挑战性的难题。自体骨移植被认为是理想的骨移植物,但是不可避免有其局限性:取骨区并发症和取骨量有限。伴随骨移植手术的增加对填充材料数量要求的激增,推动了合成骨填充材料的发展。可降解镁合金所具有的金属材料特性,其强度、塑性等都要远优于现已开始临床应用的钙磷陶瓷、硫酸钙和聚乳酸等可吸收材料,同时其弹性模量和密度更接近骨组织,因而具有在骨填充修复方面临床应用的优势和潜力。

Bone defects are very challenging in orthopedic practice. There are many practical and clinical shortcomings in the repair of the defects by using autografts, allografts or xenografts, which continues to motivate the search for better alternatives. Magnesium-based metals have been increasingly studied in the past decade, and most studies are involved in their potential to be used as biodegradable implants due to their bio-compatibility combined with outstanding physical and mechanical properties. Their mechanical strength, degradation rate and bio-compatibility are taken as predominant advantages compared with commercialized bone substitutes. Thus, biodegradable Mg-based metals can be potential candidates as bone graft substitutes for future orthopaedic applications.