人类着色性干皮病基因D基因多态性与前列腺癌易感性的Meta分析

Impact of xeroderma pigmentosum group D gene polymorphism on the risk of prostate cancer:a Meta-analysis

目的：评价人类着色性干皮病基因DAsn312Asp和Gln751Lys多态性位点对于前列腺癌患病风险的影响。方法检索2004年至2014年间在PubMed、Embase、万方、中国知网、维普等数据库中所有相关文献，提取其中数据进行统计学分析。以比值比和95％可信区间评价该位点与前列腺癌易感性的关系。分析软件使用STATA10．0。结果最终筛选出9项研究，分别有3165例前列腺癌患者和3539例对照人群涉及Gln751Lys基因多态性，2555例及3182例对照涉及Asn312Asp基因多态性。总体上，未发现XPDGln751Lys基因多态性与前列腺癌易感性相关。另一方面，在种族亚组中发现Asn312Asp多态性能增加亚洲（如：Asnvs．Asp：OR＝1．54，95％CI＝1．24～1．91）及非洲人群（如：Asnvs．Asp：OR＝1．36，95％CI＝1．00～1．83）罹患前列腺癌的易感性。结论我们的荟萃分析证实，XPDAsn312Asp基因多态性能增加亚洲人群及非洲人群罹患前列腺癌的易感性。

Objective To evaluate the effect of xeroderma pigmentosum group D （XPD） gene polymorphism on the sus‐ceptibility of prostate cancer （PCa） .Methods All eligible studies in databases including Pubmed ,Embase ,WanFang ,CNKI and VIP were searched and data were collected .The association between XPD gene polymorphismand and risk of PCa was e‐valuated with odds ratio （ OR ） and 95% confidence intervals （ CI ） .Statistical analysis was performed with STATA 10 .0 . Results A total of 9 independent case‐control studies with 3 165 PCa patients and 3 539 healthy controls for XPD Gln751Lys SNP （single nucleotide polymorphism） and 2 555 cases and 3 182 controls for Asn312Asp SNP were collected .No significant as‐sociation was found between XPD Gln751Lys SNP and PCa risk .On the other hand ,in subgroup analysis based on ethnicity , associations were observed in Asian （eg .Asn vs .Asp：OR=1 .34 ,95% CI=1 .16-1 .55） and African （eg .Asn vs .Asp：OR=1 .31 ,95% CI=1 .01-1 .70） populations with Asn 312Asp SNP .Conclusion Our investigations demonstrate that XPD Asn 312Asp SNP ,instead of Gln751Lys SNP ,might increase PCa risk in Asians and Africans .