男方年龄对常规体外受精助孕妊娠结局的影响

Effects of paternal age on reproductive outcome of conventional IVF-ET

目的分析男方年龄对于小于38岁妇女进行常规体外受精IVF）助孕妊娠结局的影响。方法回顾性分析2012年在我中心进行常规IVF助孕治疗的夫妇，选取女方年龄小于38岁，具有正常的基础卵巢储备[卵泡生成激素（FSH）〈12IU／L和基础窦卵泡数〉8个，排除多囊卵巢综合征患者]的815对夫妇，根据男方年龄分为两组：〈40岁组（n=759）及／〉40岁组（n=56），比较两组间男方精液指标、生化妊娠率、临床妊娠率、流产率、活产率、新生儿体重、新生儿性别比的差异。结果男方年龄在22岁至55岁之间时，〈40岁组与≥40岁组男方精液指标无明显差异，生化妊娠率、临床妊娠率、流产率、活产率、新生儿体重、新生儿性别比在两组间存在差异，但没有统计学意义。结论男方年龄在22~55岁之间时，对于小于38岁妇女进行常规IVF助孕妊娠结局没有明显的影响。

Objective The aim of this study was to assess the effect of patemal age on the reproductive outcome of women〈38 years after conventional IVF-ET. Methods Retrospective analysis of 815 couples underwent conventional IVF-ET in our center in 2012, which women were〈38 years with normal baseline ovarian reserve testing （FSH〈12 IU/L and basal antral follicle count〉8, exclude the polycystie ovarian syndrome）, base on the paternal age, 815 couples were divided into two groups：〈40 years （n=759） and ≥40 years （n=56）, we observed the biochemical pregnancy rate, clinical pregnancy rate, abortion rate, live birth rate, neonatal birth weight, birth defects and the sex ratio among newborns in two groups. Results When the paternal age was between 22 and 55 years, there was no significant difference of biochemical pregnancy rate, clinical pregnancy rate, abortion rate, live birth rate, neonatal birth weight, birth defects and the sex ratio among newboms between〈40 years and ≥40 years groups. Conclusion When the paternal age is between 22 and 55 years, there is no effect of paternal age on the reproductive outcome of women〈38 years after conventional IVF-ET.