生物制造工程人体脊柱骨支架的快速成型制造评估

Rapid Prototyping Evaluating of Human Vertebra Scaffold in Bio Manufacturing Engineering

以人体脊柱骨CT片为例,通过计算机软件将CT原片转换为三维CAD模型,采用快速成型制造工艺对其进行制造模拟,以评估快速成型制造方法在支架宏观结构上实现的优越性.并以目前较成功的PLGA/TCP生物降解材料为制造材料,在快速成型机上制造骨内部拓扑结构样本,最后对PLGA/TCP生物支架样本进行细胞种植与培养,以评估这种用快速成型制造方法制造的生物支架在支架微观结构上实现的优越性.

This paper deals with the CT pictures of human vertebral column, which are transferred into CAD model by the computer software, so that the exact data can be acquired for manufacturing by rapid prototyping machine. In addition, we made the scaffold samples by rapid prototyping machine using PLGA/TCP biodegradable material, then plant the stem cells（hMSCs） in this biodegradable scaffold to prove the important function of rapid prototyping in the tissue engineering.