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内质网氨基肽酶1与强直性脊柱炎相关研究进展

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摘要 AS是一种遗传相关性显著的血清阴性SpA.以骶髂关节、中轴骨骼的慢性炎症为主,可引起附近肌腱骨附着点和椎间盘纤维环的钙化和新骨形成,严重者发生脊柱畸形和骨性强直,并常伴有不同程度的胃肠道、眼等关节外表现.AS已被公认具有高度的遗传性,具有明显的家族遗传倾向.研究显示,90％以上的易感性由遗传因素决定.
作者 张宸 徐卫东
机构地区 第二军医大学附属长海医院关节骨病外科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2015年第9期634-637,I0001,共5页 Chinese Journal of Rheumatology
基金 上海市科学技术委员会科研计划项目（14140903802）
关键词 强直性脊柱炎 氨基肽酶 内质网 椎间盘纤维环 遗传相关性 关节外表现 骶髂关节 血清阴性
分类号 R593.23 [医药卫生—内科学]
  • 相关文献

参考文献25

  • 1Sarah K, Liye C, Jennifer P, et al. ERAPI and ankylosing spondylitis[J]. Curr Opin Immunol, 2013, 25( 1 ) : 97-102.
  • 2Welleome Trust Case Control Consortium, Australo-Anglo- American Spondylitis Consortium (TASC), Burton PR, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants[J]. Nat Genet, 2007, 39(11): 1329-1337.
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二级参考文献23

  • 1Pedersen OB, Svendsen AJ,Ejstrup L, et al. Herilability estimates on ankylosing spondylitis. Clin Exp Rheumatol? 2006, 24: 463.
  • 2Thomas GP, Brown MA. Genomics of ankylosing spondylitis. Discovery Medicine, 2010,52: 263-271.
  • 3Brown MA. Genetics of ankylosing spondylitis. Curr Opin Rheumatol, 2010,22: 126-132.
  • 4Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet, 2007, 39: 1329-1337.
  • 5Saric T,Chang SC, Hattori A, et al. An IFN-gamma-induced aminopeptidase in the ER, ERAPI, trims precursors to MHC class I-presented peptides. Nat Immunol,2002, 3: 1169-1176.
  • 6Australo-Anglo-American Spondyloarthritis Consortium (TASC), Reveille JD, Sims AM, et al. Genomewide association study of ankylosing spondylitis identifies multiple non-MHC susceptibility loci. Nat Genet, 2010, 42: 123-127.
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  • 10Choi CB,Kim TH, Jun JB, et al. ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans. Ann Rheum Dis, 2010,69: 582-584.

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中华风湿病学杂志
2015年 第9期

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