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早期类风湿关节炎血清生物学标志物的研究进展

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摘要 RA是一种以慢性、侵蚀性、多关节炎为主要表现的全身性自身免疫病,未经治疗的RA最终可出现不可逆的关节畸形和功能丧失,给患者及社会带来了沉重的经济负担.国家统计局公布的2006年第二次全国残疾人抽样调查的数据显示,因关节病变导致的肢体残疾在女性中占第一位,其中70%以上为RA所致.因此,早期诊断与规范治疗对于预防RA导致的肢体残疾至关重要.近年来,早期类风湿关节炎(early rheumatoid arthritis,ERA)血清中生物标志物的研究越来越受到关注.本研究通过综述了近10年有关病程<1年的ERA患者血清生物标志物的研究文献,总结其对ERA分类诊断及预测的价值,希望有助于早期RA的分类诊断与早期治疗,为改善患者的预后、提高生活质量提供帮助.
作者 郭乾育 苏茵
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2015年第9期640-643,共4页 Chinese Journal of Rheumatology
基金 北京市自然科学基金(7122192)
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