神经节苷脂对急性CO中毒的脑功能保护作用观察

Observation of cerebral protective effect of ganglioside on acute CO poisoning

目的 观察神经节苷脂对急性一氧化碳中毒脑功能的保护作用。方法 选择我院收治的68例急性一氧化碳中毒患者为研究对象,随机分为对照组和观察组,对照组采用常规对症支持治疗,观察组在对照组的基础上加用神经节苷脂治疗。比较2组治疗前后血浆NO、LPO、SOD水平及脑干听觉诱发电位（BAEP）改善情况。结果 观察组治疗后NO、LOP、SOD改善情况显著优于对照组,2组治疗后Ⅰ波异常率、Ⅴ波异常率、Ⅰ∽Ⅴ波异常率、BAEP总异常率均显著低于治疗前,观察组改善效果更显著。结论 在常规治疗的基础上给予神经节苷脂治疗急性一氧化碳中毒,具有明显的改善脑功能作用,值得临床推广。

Objective To observe cerebral protective function of ganglioside in patients with acute carbon monoxide poi‐soning. Methods 68 cases with acute CO poisoning were chosen as the research object and randomly divided into control group and observation group ,patients in control group were treated with routine symptomatic and supportive treatment ,the observa‐tion group received ganglioside on the basis of in the control group. Plasma NO and LPO ,SOD levels and brainstem auditory e‐voked potential （BAEP） were compared in two groups before and after treatment to assess the situation improvement. Results After treatment the plasma NO ,LOP and SOD levels in observation group were significantly better than that in control group. Besides ,compared with before treatment ,the abnormal rate of Ⅰ wave , Ⅴ wave , Ⅰ ‐ Ⅴ wave and the total abnormal rate of BAEP in two groups after treatment were significantly lower ,especially in observation group. Conclusion On the basis of routine treatment ,ganglioside can effectively improve cerebral function in acute CO poisoning patients ,which should be wor‐thy of clinical popularization and application.