异基因造血干细胞移植后偏肺病毒合并巨细胞病毒感染1例

Human metapneumovirus and cytomegalovirus coinfection in an ailogeneic hematopoietic stem cell transplant recipient one case

目的报道1例急性非淋巴细胞白血病患者异基因造血干细胞移植后发生巨细胞病毒（cMV）合并偏肺病毒（hMPV）感染病例，并监测其hMPV排毒时间。方法定期采集患者咽拭子和痰样本，采用实时荧光定量聚合酶链反应的方法测定样本中hMPV的拷贝数。结果该患者的咽拭子和痰中hMPV持续阳性至发病后第41天。结论免疫功能低下患者感染hMPV可长期无症状排毒，临床医生需要给予动态监测，并做好预防院内感染的措施。

Objective To report the occurrence of lower respiratory tract disease associated with cytomegalovirus and hMPVcoinfection in a patient after allogeneic hematopoietic stem cell transplantation （HSCT） for acute non-lymphocytic leukemia, and to monitor the shedding time of hMPV. Methods Patient＇s oropharyngeal swab and sputum samples periodically were collected, hMPV copies in these sampes were determined by real-time polymerase chain reaction. Results Repeat oropharyngeal swab and sputum samples was positive for hMPV until 41th day after onset. Conclusions Immunocompromised patients infected with hMPV will show as prolong viral shedding with asymptomatic and the clinician must pay more attention on immunocompromised patients for viral shedding, and prevent cross infection in the ward.