肺挫伤患者早期超敏C反应蛋白、D-二聚体及肌钙蛋白I水平的临床意义

The clinical significance of hypersensitive C-reactive protein, D-dimer, and troponin I levels in patients with early-stage lung contusion

目的观察超敏C反应蛋白(hs-CRP)、D-二聚体(DD)及肌钙蛋白I(c Tn I)在肺挫伤后急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者中的变化情况,探讨其临床意义。方法对128例急性肺挫伤患者入科24小时内测定hs-CRP、DD、c Tn I水平,追踪观察1周内患者伤情变化,终点事件为ARDS。依据检测结果分为ARDS组和对照组。结果 128例肺挫伤患者中1周内发生ARDS 29例。ARDS组hs-CRP、DD和c Tn I值分别为(7.89±3.24)mg/L、(5.32±2.14)μg/ml和(2.34±1.04)ng/ml,均明显高于对照组的(6.08±2.46)mg/L、(4.26±2.08)μg/ml和(1.87±0.98)ng/ml(P<0.05)。结论hs-CRP、DD及c Tn I水平可以作为肺挫伤后ARDS的病情评估指标。

Objective To observe the variation of hypersensitive c-reactive protein （hs-crP）, d- dimer （dd） and troponin i （cTni） patients with acute respiratory distress syndromes（ards）after lung contusion and to explore its clinical significance.Method Hs-crP, dd, cTni levels of 128 patients with acute pulmonary contusion were measured within 24 hours after being enrolled into the department and their injury condition was followed up for a week with ards defined as the clinical endpoint. Based on the test results, they were divided into the ards and the normal group.Result 29 cases of ards occurred in 128 patients with pulmonary contusion within 1 week. Hs-crP value, dd value and cTni value in the ards group were （7.89 ±3.24）mg/l,（5.32±2.14）μg/ml,and（2.34±1.04）ng/ml,respectively,significantly higher than those of the control group which were（6.08±2.46）mg/l,（4.26±2.08）μg/ml,（1.87±0.98）ng/ml（P〈0.05）. Conclusion Hs-crP, dd and cTni levels can be used as indicators to assess the ards after lung contusion.