环孢霉素A睾丸毒性的研究进展

Advances in research on testis toxicity produced by cyclosporine A

环孢霉素A(cyclosporine A,CsA)是器官移植手术后常用的一种免疫抑制剂,其长期使用后产生的睾丸毒性不容忽视,严重影响了器官移植患者正常的生育能力。为探讨CsA对生殖系统的损伤,该文从其对生殖器官发育的影响、对生殖系统损伤的作用机制以及目前缓解CsA生殖毒性的药物研究等方面进行了阐述,旨在引起广大医学工作者对CsA生殖毒性的关注和重视,同时为研制开发缓解CsA生殖毒性的药物提供借鉴。

Cyclosporine A（CsA）, as an immune inhibitor, is commonly used after organ transplantation. It has been found that the long-term use of CsA produced serious testicular toxicity and affected the fertility of organ transplantation patients. In order to investigate male reproductive damage induced by CsA, this article reviews its impact on reproductive organ development, its damage mechanism on the male reproductive system and drug research for alleviating its reproductive toxicity. It helps to make medical workers pay more attention to reproductive toxicity produced by CsA and make their efforts to develop some special drugs to lessen CsA reproductive toxicity.