不同剂量舒芬太尼用于喉罩插入前的诱导效果及安全性研究

Induction Effect and Safety of Different Doses of Sufentanil before Laryngeal Mask Insertion

目的观察不同剂量舒芬太尼用于腹腔镜手术全麻患儿喉罩插入前麻醉诱导效果及安全性。方法将120例患儿随机均分为A组,B组和C组,分别给予0.1,0.2,0.3μg/kg舒芬太尼麻醉诱导。结果 3组患儿喉罩1次插入成功率和喉罩插入时间比较,差异无统计学意义(P>0.05);B组及C组患儿呼吸暂停时间显著长于A组,C组更长(P<0.05);B组及C组患儿喉罩插入评分满意度均显著优于A组(P<0.05);3组患儿T1时平均动脉压(MAP)和心率(HR)水平均显著低于T0(P<0.05);A组患儿T2时MAP和HR水平均显著高于T0时及B组和C组(P<0.05);3组患儿T4时MAP和HR均显著低于T0(P<0.05)。结论全麻喉罩插入下行腹腔镜手术治疗患儿给予0.2μg/kg舒芬太尼用于麻醉诱导,可有效改善喉罩插入效果,提高血流动力学稳定性,效果及安全性均较好,值得临床推广。

Objective To investigate the effect and safety of different doses of sufentanil for anesthetic induction before laryngeal mask insertion in children with laparoscopic operation under general anesthesia. Methods Totally 120 children patients were randomly divided into the group A,B and C,which were given with sufentanil 0. 1,0. 2,0. 3 μg/kg for anesthesia induction respectively. Results There was no statistically significant difference in the once successful rate of laryngeal mask insertion and laryngeal mask insertion time among the 3 groups（ P ﹥ 0. 05）;the apnea time of the group B and C was significantly longer than that of the group A,moreover the group C was significantly longer（ P ﹤ 0. 05）;the satisfaction of laryngeal mask insertion score in the group B and C was significantly better than that in the group A（ P ﹤ 0. 05）;the levels of MAP and HR at T1 in the 3 groups was significantly lower than those at T0（ P ﹤ 0. 05）;the levels of MAP and HR at T2 in the group A were significantly higher than those at T0 and the group B and C（ P ﹤ 0. 05 ）;the levels of MAP and HR at T 4 in 3 groups were significantly lower than those at T 0（ P ﹤ 0. 05 ）. Conclusion Giving sufentanil 0. 2 μg/kg for anesthetic induction before laryngeal mask insertion in children patients with laparoscopic operation under general anesthesia can effectively improve the laryngeal mask insertion effect and increase the hemodynamic stability,has better effect and good safety and is worthy of clinical promotion.