致康胶囊治疗节育器致异常出血105例

Zhikang Capsules for Treating Abnormal Bleeding Caused by IUD in 105 Cases

目的观察致康胶囊治疗节育器致异常出血的临床疗效。方法选择宫内节育器致异常出血患者210例,随机分为对照组和观察组,各105例。对照组患者术后口服云南白药,观察组患者术后服用致康胶囊。结果观察组的总有效率为76.19%,显著高于对照组的68.57%(P<0.05);两组患者术后首个月经周期出血量及行经时间无明显差异,但均高于术前;对照组术后3个月出血量及行经时间仍显著高于术前水平及观察组水平,而观察组行经时间较术前未见明显差异;术后3个月,两组患者血红蛋白含量均明显低于术前水平(P<0.05),但组间无明显差异(P>0.05);术后6个月时,观察组患者的血红蛋白含量已恢复至术前水平,而对照组较术前及同期观察组仍明显偏低(P<0.05);术前及术后3个月,两组患者血清铁水平无明显差异,但术后6个月时两组患者血清铁水平均有下降(P<0.05),但组间无明显差异;两组患者不良反应发生率无明显差异。结论致康胶囊治疗宫内节育器致阴道出血疗效确切,可明显降低月经出血量和出血时间,且安全性良好。

Objective To investigate the clinical effect of Zhikang Capsules in treating abnormal bleeding caused by intrauterine device （IUD）. Methods Totally 210 patients with abnormal bleeding caused by IUD were randomly divided into two groups,105 cases in each group. The control group was given Yunnanbaiyao after operation,while the observation group was given Zhikang Capsules. Results The total effective rate in the observation group was 76. 19%,which was significantly higher than 68. 57% in the control group（ P ﹤ 0. 05）;after the first menstrual cycle,the bleeding volume and the menstrual period had no significant difference between the two groups,but significantly higher than pre-operation;3 months after operation,the bleeding volume and the menstrual period were still significantly higher than pre-operation,and also significantly higher than those in the observation group（ P ﹤ 0. 05）,but the menstrual period of the observation group had no significantly difference compared with pre-operation;3 months after operation,the hemoglobin content of the two groups was significantly lower than pre-operation（ P ﹤0. 05）,but there was no significant difference between the two groups（ P ﹥ 0. 05）;6 months after operation,the hemoglobin content in the observation group had returned to pre-operation level,but the hemoglobin content in the control group was significantly lower than that in the observation group and pre-operation level（ P ﹤ 0. 05）;the serum iron level of the two groups had no significantly difference before operation and 3 months after operation,but it significantly decreased at 6 months after operation（ P ﹤ 0. 05）,and had no significantly difference between the two groups;the occurrence rate of the adverse reactions had no significant difference between the two groups. Conclusion Zhikang Capsules in treating abnormal bleeding caused by IUD has good effect,can significantly reduce the bleeding volume and the menstrual period,and it has good safety.