深圳市2523例妊娠梅毒患者性伴的梅毒感染情况分析

Analysis on syphilis infection among 2523 partners of pregnant women infected with syphilis in Shenzhen

目的 了解妊娠梅毒患者性伴的梅毒感染情况及相关影响因素。方法 对确诊的妊娠梅毒患者进行随访和性伴追踪,对就诊的性伴采用甲苯胺红不加热血清试验（TRUST）和梅毒螺旋体明胶颗粒凝集试验（TPPA）检测。通过结构化问卷收集性伴相关信息。结果 2008-2011年间,深圳市共确诊妊娠梅毒患者3551例,其中2523例患者的性伴自愿到产前门诊就诊并进行梅毒血清学检测,妊娠梅毒患者性伴的检测率为71.05%。接受调查的性伴中,577例TRUST和TPPA检测均阳性（22.87%）,134例仅TPPA阳性（5.31%）,妊娠梅毒患者性伴的梅毒感染率为28.18%（711/2523）。多因素Logistic回归模型结果显示,年龄、婚姻状态、文化水平、职业和多性伴与性伴感染梅毒有关。多性伴者感染梅毒的风险是单一性伴者的1.55倍[比值比（OR）=1.55,95%可信区间（CI）=1.26~1.90]。结论 妊娠梅毒患者性伴的梅毒感染率较高,多性伴行为是性伴感染梅毒的重要危险因素。

Objective To understand status of syphilis infection among partners of pregnant women infected with syphilis and its associated factors. Methods Follow-up survey and contact tracing were conducted among pregnant women infected with syphilis. Both toludine red unheated serum test （TRUST） and treponema pallidum particee ag- glutination （TPPA） test were provided to partners attending to the antenatal care clinic. Structural questionnaires were applied to collect information. Results From the year of 2008 to 2011, 3551 pregnant women infected with syphilis were identified in Shenzhen and 2523 partners attended the clinic to have syphilis serological examination, with a rate of 71.05%. There were 577 partners with positive results for both TRUST and TPPA test （22.87%）, and 134 partners with positive results for only TPPA （5.31%）; thus syphilis infection rate among partners was 28.18% （711/2523）. Results from multivariate logistic regression model showed that the syphilis infection rate var- ied from different age, marital status, education level, occupation and number of sex partners. Syphilis infection rate among partners who had 〉1 sex partners was 1.55 times as high as that had only one partner （OR= 1.55, 95 %CI= 1.26-1.90）. Conclusion Syphilis infection rate among partners of pregnant women infected with syphilis was high, and owning multiple sex partners was a risk factor associated with their syphilis infection.