联合检测血清肿瘤标志物对结肠癌根治术后患者复发转移的预测价值

Predictive value of combined detection of serum tumor markers for recurrence or metastasis of colon cancer after radical surgery

目的探讨结肠癌患者根治性手术后血清低氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)、癌胚抗原(CEA)和糖类抗原125(CA125)表达水平在预测复发转移中的临床应用价值。方法回顾性研究2009年7月至2013年12月根治术后结肠癌患者共123例,动态分析血清标志物水平变化与复发转移间的相关性。结果 (1)123例患者术后HIF-1α和CEA水平较术前下降(P<0.05);(2)39例复发转移患者的HIF-1α、CEA和CA125较84例未复发转移患者升高(P<0.05);(3)39例复发转移患者,复发转移时HIF-1α和CEA表达水平较化疗结束后明显升高(P<0.05);(4)HIF-1α与VEGF呈正相关(P<0.05)。结论 HIF-1α和CEA表达水平与复发转移呈正相关,动态联合监测血清标志物HIF-1α和CEA对预测和早期发现根治术后结肠癌的复发转移、改善预后具有重要意义。

Objective To explore the clinical application value of the expression levels of serum hypoxia induced factor-1α（HIF-1α）,vascular endothelial growth factor（VEGF）,carcino-embryonic antigen（CEA）and CA125 in predicting the recurrence or metastasis of colon cancer after radical resection.Methods Totally 123 cases of colon cancer after radical surgery in our hospital from July 2009 to December 2013 were performed the retrospective analysis.The correlation between the serum markers levels with the recurrence or metastasis was dynamically analyzed.Results（1）The HIF-1αand CEA levels after operation in 123 cases of colon cancer were decreased significantly compared with before operation;（2）The HIF-1α,CEA and CA125 levels in 39 cases of recurrence or metastasis were significantly increased compared with those in 84 cases of non-recurrence or non-metastasis（P〈0.05）;（3）in 39 cases of recurrence or metastasis,the HIF-1αand CEA levels in recurrence or metastasis were increased significantly compared with those after the end of chemotherapy（P〈0.05）;（4）HIF-1αwas positively correlated to VEGF（P〈0.05）.Conclusion The serum levels of HIF-1αand CEA in the patients with colon cancer are positively correlated with recurrence or metastasis,the dynamically combined detection of serum markers has an important significance for predicting and early find recurrence or metastasis after radical operation in colon cancer.