心肺脑复苏患者血液中脑红蛋白及N端脑钠肽前体的表达意义

Significance of Expression of Neuroglobin and N-Terminal Pro-Brain Natriuretic Peptide on Patients with Cardiopulmonary Cerebral Resuscitation

目的探讨脑红蛋白(neuroglobin,NGB)及N端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-pro BNP)在心肺脑复苏中的变化与意义。方法 126例心搏骤停(cardiac arrest,CA)患者按抢救结果分为A组:心肺脑复苏30 min无自主循环,或有自主循环但<48 h;B组:自主循环恢复≥48 h,未能存活出院;C组:抢救成功,存活出院。于心肺脑复苏0 h(即刻)、3 h、12 h、24 h、48 h留取静脉血,测定血清中NGB和血浆中NT-pro BNP的含量。结果在0 h,NT-pro BNP无明显变化,各组比较,P>0.05,而NGB,各组比较,P<0.05;B组NGB、NT-pro BNP表达随时间延长总趋势明显增高,而C组则是明显降低,C组与B组比较,P<0.05,其中NGB在B组中的12 h有降低,NT-pro BNP在C组中的12 h有增高。结论检测血液中NGB、NT-pro BNP可反映心肺脑复苏的效果与预后,但NGB的表达更提前。

Objective To investigate the change and significance of neuroglobin （NGB） and N-terminal pro-brain natriuretic peptide （NT-proBNP） during cardiopulmonary cerebral resuscitation （CPCR）. Methods 126 patients with cardiac arrest （CA） were selected in this study. According to saving results, all patients were divided into three groups： （1）Group A： without recovery of spontaneous circulation （ROSC） after 30 min of CPCR, or ROSC 〈 48 h; （2）Group B： ROSC ≥ 48 h, but failed to survive ; （3）Group C： successful rescue, live out of the hospital. The levels of NGB and NT-proBNP in blood were determined at the time of 0, 3, 12, 24, 48 h after CPCR. Results The level of NT-proBNP had no significant difference of each group at 0 h （P 〉0.05）, while the level of NGB had obvious significant difference at 0 h among each group （P 〈0.05）. The general expression trends of NGB and NT- proBNP in group B were significantly increased with the extension of time, and decreased significantly in group C; The differences between group B and group C were statistically significant （P〈0.05）; In which, the level of NGB decreased in group B at 12 h, and NT-proBNP increased in group C at 12 h. Conclusions Detection of NGB and NT-proBNP in the blood can reflect the effect and prognosis of CPCR, but the expression of NGB is more in advance.