阿托伐他汀钙治疗脑梗死的效果及作用机制研究

Study on the Effect and Mechanism of Action of Atorvastatin Calcium in the Treatment of Cerebral Infarction

目的探讨阿托伐他汀钙治疗脑梗死的效果及作用机制。方法选取我院收治的132例脑梗死患者,将其随机分为观察组和对照组各66例,对照组给予常规治疗,观察组患者在对照组的基础上给予阿托伐他汀钙进行治疗,比较两组患者治疗后血脂水平、颈动脉内中膜厚度(IMT)、超敏-C反应蛋白(Hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、细胞间粘附分子-1(ICAM-1)、动脉粥样硬化斑块变化情况及神经功能。结果观察组TC、TG、LDL-C、IMT、Hs-CRP、IL-6、TNF-α、ICAM-1、神经功能缺损评分及动脉粥样硬化斑块直径、厚度、面积、积分均明显低于对照组,组间差异有显著统计学意义(P<0.01);观察组HDL-C明显高于对照组,组间差异有显著统计学意义(P<0.01)。结论阿托伐他汀钙可有效改善脑梗死患者血脂水平,降低炎性反应,消除动脉粥样硬化斑块,改善神经功能,临床效果显著,值得推广。

Objective To investigate the effect and mechanism of action of atorvastatin calcium in the treatment of cerebral infarction. Methods 132 cases of patients with cerebral infarction admitted to our hospital were selected in this study and randomly divided into the observation group and the control group, with 66 cases in each group. All patients were given conventional treatment; in addition, patients in the observation group were treated with atorvastatin calcium. The lipid levels, carotid artery intima-media thickness （IMT）, hypersensitivity -C-reactive protein （Hs-CRP）, intedeukin-6 （IL-6）, tumor necrosis factor a （TNF-a）, intercellular adhesion molecule -1 （ICAM-1）, atherosclerotic plaques and neurological changes of two groups after treatment were compared. Results The levels of TC, TG, LDL-C, IMT, Hs-CRP, IL-6, TNF-c~ and ICAM-1, neurological deficit score, and the diameter, thickness, area and point of atherosclerotic plaque of observation group were significantly lower than those of control group （P〈0.01）, and the HDL-C level of observation group was significantly higher than that of control group （P〈0.01）. Conclusions Atorvastatin calcium has significant clinical efficacy for the treatment of cerebral infarction, which can effectively improve blood lipid levels of patients, reduce inftammation, eliminate atherosclerotic plaques, and improve nerve function.