固尔苏与CPAP联合治疗新生儿呼吸窘迫综合征的临床观察

Clinical Observation of Curosurf Combined with CPAP for the Treatment of Neonatal Respiratory Distress Syndrome

目的探讨新生儿呼吸窘迫综合征采用CPAP联合固尔苏治疗的临床效果。方法将44例呼吸窘迫综合征新生儿随机分为两组,参照组患儿单纯采用CPAP进行治疗,而联合组患儿实施CPAP联合小剂量的固尔苏进行治疗,比较两组患儿治疗24小时后的临床效果。结果联合组治疗总有效率为90.91%,显著高于参照组的63.64%,差异具有统计学意义(P<0.05)。联合组p H、Pa CO2、Pa O2等指标明显优于参照组,差异具有统计学意义(P<0.05)。联合组用氧时间、住院时间及并发症发生率均显著低于参照组,差异具有统计学意义(P<0.05)。结论对呼吸窘迫的新生儿实施CPAP联合固尔苏进行治疗具有显著效果,值得临床推广应用。

Objective To investigate the clinical efficacy of curosurf combined with CPAP for the treatment of neonatal respiratory distress syndrome. Methods 44 cases of neonatal respiratory distress syndrome were randomly divided into two groups, with 22 cases in each group. The control group was treated with simple CPAP, while the combined group was treated with curosurf and CPAP. After 24-hour＇s treatment, the clinical effects of two groups were compared. Results The total effective rate of combined group was 90.91%, significantly higher than 63.64% of control group （P〈0.05）. After treatment, the combined group was superior to the control group in pH, PaCO2 and PaO2 levels （P〈0.05）. The oxygen supply time, length of hospital stay and incidence of complications of combined group were significantly lower than those of control group （P 〈0.05）. Conclusions Curosurf combined with CPAP for the treatment of neonatal respiratory distress syndrome has significant efficacy, which is worthy of clinical promotion.