连续性血液净化对重症急性胰腺炎患者肾素-血管紧张素-醛固酮系统及炎性指标的影响

Influence of Continuous Blood Purification on Rennin-Angiotensin-Aldosterone System and Inflammatory Markers of Patients with Severe Acute Pancreatitis

目的探讨重症急性胰腺炎行连续性血液净化对患者肾素-血管紧张素-醛固酮系统(RAAS)以及患者炎性指标的影响,从而验证该治疗方法临床效果。方法从我院2010年3月至2014年3月收治的重症急性胰腺炎患者中选取139例为研究对象,根据治疗方法分为观察组79例,对照组60例,对照组行常规治疗,观察组在对照组基础上行连续性血液净化治疗,观察两组患者治疗前后炎性指标变化情况及RAAS指标变化情况。结果两组患者治疗前相关指标无统计学差异(P>0.05),治疗后观察组炎性指标及RAAS指标显著低于对照组,差异存在统计学意义(P<0.05)。结论在重症急性胰腺炎患者治疗中,采用连续性血液净化疗法,能有效改善炎性指标,提高治疗效果,为高效治疗方法,值得临床推广应用。

Objective To explore the influence of continuous blood purification on rennin-angiotensin-aldosterone system （RAAS） and inflammatory markers of patients with severe acute pancreatitis, thus to verifie the clinical effects of the treatment. Methods 139 patients with severe acute pancreatitis admitted to our hospital from March 2012 to March 2014 were selected as the research objects, and divided into two groups according to the treatment. 60 cases of control group were given routine treatment, and 79 cases of observation group were given continuous blood purification on the basis of routine treatment. The changes of RAAS indicators and inflammatory markers before and after treatment of two groups were observed. Results No statistical difference was found between two groups in all the indicators （P 〉0.05）. After treatment, the observation group was superior to the control group in the RAAS indicators and inflammatory markers, and all the differences were statistically significant （P〈0.05）. Conclusions Continuous blood purification for patients with severe acute pancreatitis can effectively improve inflammatory markers and curative effect, which is worthy of clinical promotion.