检测围排卵期宫颈黏液中性激素的临床意义

Evaluation of Sexual Hormone in Human Cervical Mucus during Peri-ovulatory Period

目的:检测排卵前后人类宫颈黏液中雌孕激素及黄体生成激素(LH)分泌水平的变化。方法:宫颈黏液标本来自20名育龄女性,同时采集外周血,通过B型超声确认排卵。采用化学发光免疫分析法检测血液及宫颈黏液中雌二醇、孕激素及LH的浓度变化。结果:宫颈黏液中存在雌二醇和孕激素以及LH,其分泌模式与外周血相似,雌激素峰、LH峰发生在排卵前1 d,且孕激素分泌在排卵前1 d开始升高,但激素分泌浓度显著低于外周血。结论:检测围排卵期宫颈黏液中性激素水平对识别排卵有参考价值。

Objective： To evaluate the levels of estradiol,progesterone and luteinizing hormone （LH） in human cervical mucus around ovulation. Methods：Human cervical mucus and serum samples were collected from twenty adult heathy women during the peri -ovulation. Levels of three hormones were tested using the chemiluminescent immunoassay. Ovulation was confirmed by B ultrasound. Results：The secreting models of the estradiol,progesterone and LH existed in human cervical mucus were similar with those in peripheral blood. There were the estradiol peak and the LH peak on the 1 day before ovulation. The level of progesterone was elevated from this day. However, the levels of three hormones in cervical mucus were significantly lower than those in blood. Conclusions：It could be beneficial to predict ovulation to test the sexual hormones existed in cervical mucus during periovulation.